Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is largely responsible for alterations in cell metabolism in hypoxic tumor cells. This transcription factor not only favors cell proliferation through the metabolic shift from oxidative phosphorylation to glycolys...

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Bibliographische Detailangaben
Hauptverfasser: Pelletier, Joffrey, Bellot, Grégory, Gounon, Pierre, Lacas-Gervais, Sandra, Pouysségur, Jacques, Mazure, Nathalie M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Research Foundation 2012
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355943/
https://ncbi.nlm.nih.gov/pubmed/22649778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00018
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