Local Mitochondrial-Endolysosomal Microfusion Cleaves Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia

The oxygen-limiting (hypoxic) microenvironment of tumors induces metabolic reprogramming and cell survival, but the underlying mechanisms involving mitochondria remain poorly understood. We previously demonstrated that hypoxia-inducible factor 1 mediates the hyperfusion of mitochondria by inducing B...

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Udgivet i:Mol Cell Biol
Main Authors: Brahimi-Horn, M. Christiane, Lacas-Gervais, Sandra, Adaixo, Ricardo, Ilc, Karine, Rouleau, Matthieu, Notte, Annick, Dieu, Marc, Michiels, Carine, Voeltzel, Thibault, Maguer-Satta, Véronique, Pelletier, Joffrey, Ilie, Marius, Hofman, Paul, Manoury, Bénédicte, Schmidt, Alexander, Hiller, Sebastian, Pouysségur, Jacques, Mazure, Nathalie M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387213/
https://ncbi.nlm.nih.gov/pubmed/25691661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01402-14
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