Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

BACKGROUND: Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response to environmental conditions. We showed previously that mitochondria of cells in a low oxygen enviro...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Brahimi-Horn, M. Christiane, Giuliano, Sandy, Saland, Estelle, Lacas-Gervais, Sandra, Sheiko, Tatiana, Pelletier, Joffrey, Bourget, Isabelle, Bost, Frédéric, Féral, Chloé, Boulter, Etienne, Tauc, Michel, Ivan, Mircea, Garmy-Susini, Barbara, Popa, Alexandra, Mari, Bernard, Sarry, Jean-Emmanuel, Craigen, William J., Pouysségur, Jacques, Mazure, Nathalie M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551760/
https://ncbi.nlm.nih.gov/pubmed/26322231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0133-5
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