Enhanced GLP-1- and Sulfonylurea-Induced Insulin Secretion in Islets Lacking Leptin Signaling

We have previously reported that the absence of leptin signaling in β-cells enhances glucose-stimulated insulin secretion and improves glucose tolerance in vivo. To investigate the relevance of β-cell leptin signaling in the context of postprandial or therapeutic insulin secretion, we examined the c...

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Autori principali: Morioka, Tomoaki, Dishinger, John. F., Reid, Kendra. R., Liew, Chong Wee, Zhang, Ting, Inaba, Masaaki, Kennedy, Robert. T., Kulkarni, Rohit. N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2012
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355538/
https://ncbi.nlm.nih.gov/pubmed/22474124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1306
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