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Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice
Obesity is characterized by hyperinsulinemia, hyperleptinemia, and an increase in islet volume. While the mechanisms that hasten the onset of diabetes in obese individuals are not known, it is possible that the adipose-derived hormone leptin plays a role. In addition to its central actions, leptin e...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1994606/ https://ncbi.nlm.nih.gov/pubmed/17909627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30910 |
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