Femtomolar Fab binding affinities to a protein target by alternative CDR residue co-optimization strategies without phage or cell surface display

In therapeutic or diagnostic antibody discovery, affinity maturation is frequently required to optimize binding properties. In some cases, achieving very high affinity is challenging using the display-based optimization technologies. Here we present an approach that begins with the creation and clon...

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Bibliografiske detaljer
Main Authors: Votsmeier, Christian, Plittersdorf, Hanna, Hesse, Oliver, Scheidig, Andreas, Strerath, Michael, Gritzan, Uwe, Pellengahr, Klaus, Scholz, Peter, Eicker, Andrea, Myszka, David, Coco, Wayne M., Haupts, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355236/
https://ncbi.nlm.nih.gov/pubmed/22531438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.19981
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