Femtomolar Fab binding affinities to a protein target by alternative CDR residue co-optimization strategies without phage or cell surface display

In therapeutic or diagnostic antibody discovery, affinity maturation is frequently required to optimize binding properties. In some cases, achieving very high affinity is challenging using the display-based optimization technologies. Here we present an approach that begins with the creation and clon...

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Main Authors: Votsmeier, Christian, Plittersdorf, Hanna, Hesse, Oliver, Scheidig, Andreas, Strerath, Michael, Gritzan, Uwe, Pellengahr, Klaus, Scholz, Peter, Eicker, Andrea, Myszka, David, Coco, Wayne M., Haupts, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355236/
https://ncbi.nlm.nih.gov/pubmed/22531438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.19981
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