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Elucidation of functions of human cytochrome P450 enzymes: Identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches
One of the central problems in biochemistry in the post-genomic era is the elucidation of functions of proteins, including “orphan” human cytochromes P450 (P450s), when the substrates are unknown. A general strategy for identification of endogenous substrates of P450s in tissue extracts using metabo...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3354960/ https://ncbi.nlm.nih.gov/pubmed/19301915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac900021a |
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