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Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches
Metabolomics provides an invaluable means to interrogate the function of “orphan” enzymes, i.e., those whose endogenous substrates are not known. Here we describe a high performance liquid chromatography-coupled mass spectrometry (HPLC-MS)-based metabolomics approach to identify an endogenous substr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3846702/ https://ncbi.nlm.nih.gov/pubmed/23475668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-321-3_6 |
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