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Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches

Metabolomics provides an invaluable means to interrogate the function of “orphan” enzymes, i.e., those whose endogenous substrates are not known. Here we describe a high performance liquid chromatography-coupled mass spectrometry (HPLC-MS)-based metabolomics approach to identify an endogenous substr...

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Bibliografski detalji
Glavni autori: Cheng, Qian, Guengerich, F. Peter.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846702/
https://ncbi.nlm.nih.gov/pubmed/23475668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-321-3_6
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