The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions: A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives

Isoxazoline γ-lactams are prepared starting from the regioisomeric cycloadducts of benzonitrile oxide to the N-alkyl 2-azanorbornenes taking advantage of the efficient catalytic oxidation by RuO(4). The reduction of the amide groups is easily conducted in the presence of LiAlH(4) under mild conditio...

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מידע ביבליוגרפי
Main Authors: Memeo, Misal Giuseppe, Mella, Mariella, Quadrelli, Paolo
פורמט: Artigo
שפה:Inglês
יצא לאור: The Scientific World Journal 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354679/
https://ncbi.nlm.nih.gov/pubmed/22629174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1100/2012/643647
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