Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent

Angiotensin II (ANG II)-induced mitogen-activated protein kinase (MAPK) signaling upregulates angiotensin II type-1 receptors (AT(1)R) in hypothalamic paraventricular nucleus (PVN) and contributes to AT(1)R-mediated sympathetic excitation in heart failure. Aldosterone has similar effects to increase...

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Autores principales: Zhang, Zhi-Hua, Yu, Yang, Wei, Shun-Guang, Felder, Robert B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2012
Materias:
Cardiovascular Neurohormonal Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353800/
https://ncbi.nlm.nih.gov/pubmed/22081704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00856.2011
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