Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na(+)/Ca(2+) exchanger

Expression and activity of cardiac Na(+)/Ca(2+) exchanger (NCX1) are altered in many disease states. We engineered mice in which the phosphomimetic phospholemman S68E mutant (inhibits NCX1 but not Na(+)-K(+)-ATPase) was constitutively overexpressed in a cardiac-specific manner (conS68E). At 4–6 wk,...

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Main Authors: Song, Jianliang, Gao, Erhe, Wang, JuFang, Zhang, Xue-Qian, Chan, Tung O., Koch, Walter J., Shang, Xiying, Joseph, Jeffrey I., Peterson, Blaise Z., Feldman, Arthur M., Cheung, Joseph Y.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
Assuntos:
Cardiac Excitation and Contraction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353790/
https://ncbi.nlm.nih.gov/pubmed/22081699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00733.2011
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