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Ribonuclease-Activated Cancer Prodrug

[Image: see text] Cancer chemotherapeutic agents often have a narrow therapeutic index that challenges the maintenance of a safe and effective dose. Consistent plasma concentrations of a drug can be obtained by using a timed-release prodrug strategy. We reasoned that a ribonucleoside 3′-phosphate co...

詳細記述

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書誌詳細
主要な著者: Ellis, Gregory A., McGrath, Nicholas A., Palte, Michael J., Raines, Ronald T.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2012
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353771/
https://ncbi.nlm.nih.gov/pubmed/22611478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2002554
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