Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, wh...

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Main Authors: Torres, Eva, Duque, María D., López-Querol, Marta, Taylor, Martin C., Naesens, Lieve, Ma, Chunlong, Pinto, Lawrence H., Sureda, Francesc X., Kelly, John M., Vázquez, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. Published by Elsevier Ltd. 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353318/
https://ncbi.nlm.nih.gov/pubmed/22178660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.11.050
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