Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a s...

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Detalhes bibliográficos
Main Authors: Duque, María D., Camps, Pelayo, Profire, Lenuta, Montaner, Silvia, Vázquez, Santiago, Sureda, Francesc X., Mallol, Jordi, López-Querol, Marta, Naesens, Lieve, Clercq, Erik De, Radhika Prathalingam, S., Kelly, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. Published by Elsevier Ltd. 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217223/
https://ncbi.nlm.nih.gov/pubmed/19251424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.02.007
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