Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog

Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activ...

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Veröffentlicht in:Tetrahedron Lett
Hauptverfasser: Leiva, Rosana, Gazzarrini, Sabrina, Esplugas, Roser, Moroni, Anna, Naesens, Lieve, Sureda, Francesc X., Vázquez, Santiago
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Ltd. 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125674/
https://ncbi.nlm.nih.gov/pubmed/32287445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.01.160
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