High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

Knowledge of “actionable” somatic genomic alterations present in each tumor (e.g., point mutations, small insertions/deletions, and copy number alterations that direct therapeutic options) should facilitate individualized approaches to cancer treatment. However, clinical implementation of systematic...

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Autori principali: Wagle, Nikhil, Berger, Michael F., Davis, Matthew J., Blumenstiel, Brendan, DeFelice, Matthew, Pochanard, Panisa, Ducar, Matthew, Van Hummelen, Paul, MacConaill, Laura E., Hahn, William C., Meyerson, Matthew, Gabriel, Stacey B., Garraway, Levi A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353152/
https://ncbi.nlm.nih.gov/pubmed/22585170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0184
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