Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing

BACKGROUND: Sample index cross-talk can result in false positive calls when massively parallel sequencing (MPS) is used for sensitive applications such as low-frequency somatic variant discovery, ancient DNA investigations, microbial detection in human samples, or circulating cell-free tumor DNA (ct...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Genomics
Egile Nagusiak: MacConaill, Laura E., Burns, Robert T., Nag, Anwesha, Coleman, Haley A., Slevin, Michael K., Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew S., Ducar, Matthew D., Meyerson, Matthew, Thorner, Aaron R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759201/
https://ncbi.nlm.nih.gov/pubmed/29310587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4428-5
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