Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing

BACKGROUND: Sample index cross-talk can result in false positive calls when massively parallel sequencing (MPS) is used for sensitive applications such as low-frequency somatic variant discovery, ancient DNA investigations, microbial detection in human samples, or circulating cell-free tumor DNA (ct...

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Udgivet i:BMC Genomics
Main Authors: MacConaill, Laura E., Burns, Robert T., Nag, Anwesha, Coleman, Haley A., Slevin, Michael K., Giorda, Kristina, Light, Madelyn, Lai, Kevin, Jarosz, Mirna, McNeill, Matthew S., Ducar, Matthew D., Meyerson, Matthew, Thorner, Aaron R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759201/
https://ncbi.nlm.nih.gov/pubmed/29310587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4428-5
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