Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation

Immune evasion is required for Mycobacterium tuberculosis to survive in the face of robust CD4(+) T cell responses. We have shown previously that M. tuberculosis cell wall glycolipids, including mannose capped lipoarabinomannan (ManLAM), directly inhibit polyclonal murine CD4(+) T cell activation by...

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Autori principali: Mahon, Robert N., Sande, Obondo J., Rojas, Roxana E., Levine, Alan D., Harding, Clifford V., Boom, W. Henry
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352599/
https://ncbi.nlm.nih.gov/pubmed/22507872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2012.02.009
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