Mannose-Capped Lipoarabinomannan (LAM) from Mycobacterium tuberculosis Induces CD4(+) T cell Anergy via GRAIL

Mycobacterium tuberculosis cell wall glycolipid, Lipoarabinomannan, can inhibit CD4(+) T cell activation by down-regulating phosphorylation of key proximal TCR signaling molecules Lck, CD3ζ, ZAP70 and LAT. Inhibition of proximal TCR signaling can result in T cell anergy, in which T cells are inactiv...

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Publicado en:J Immunol
Autores principales: Sande, Obondo J., Karim, Ahmad F., Li, Qing, Ding, Xuedong, Harding, Clifford V., Rojas, Roxana E., Boom, W. Henry
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707121/
https://ncbi.nlm.nih.gov/pubmed/26667170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500710
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