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Mannose-Capped Lipoarabinomannan (LAM) from Mycobacterium tuberculosis Induces CD4(+) T cell Anergy via GRAIL
Mycobacterium tuberculosis cell wall glycolipid, Lipoarabinomannan, can inhibit CD4(+) T cell activation by down-regulating phosphorylation of key proximal TCR signaling molecules Lck, CD3ζ, ZAP70 and LAT. Inhibition of proximal TCR signaling can result in T cell anergy, in which T cells are inactiv...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4707121/ https://ncbi.nlm.nih.gov/pubmed/26667170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500710 |
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