Proteomics and Network Analyses Reveal Inhibition of Akt‐mTOR Signaling in CD4(+) T Cells by Mycobacterium tuberculosis Mannose‐Capped Lipoarabinomannan

Mycobacterium tuberculosis (Mtb) cell wall glycolipid mannose‐capped lipoarabinomannan (ManLAM) inhibits CD4(+) T‐cell activation by inhibiting proximal T‐cell receptor (TCR) signaling when activated by anti‐CD3. To understand the impact of ManLAM on CD4(+) T‐cell function when both the TCR–CD3 comp...

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Detalhes bibliográficos
Publicado no:Proteomics
Main Authors: Karim, Ahmad F., Sande, Obondo J., Tomechko, Sara E., Ding, Xuedong, Li, Ming, Maxwell, Sean, Ewing, Rob M., Harding, Clifford V., Rojas, Roxana E., Chance, Mark R., Boom, W. Henry
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725663/
https://ncbi.nlm.nih.gov/pubmed/28994205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201700233
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