Aptamer Against Mannose-capped Lipoarabinomannan Inhibits Virulent Mycobacterium tuberculosis Infection in Mice and Rhesus Monkeys

The major surface lipoglycan of Mycobacterium tuberculosis (M. tb), mannose-capped lipoarabinomannan (ManLAM), is an immunosuppressive epitope of M. tb. We used systematic evolution of ligands by exponential enrichment (SELEX) to generate an aptamer (ZXL1) that specifically bound to ManLAM from the...

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Detalhes bibliográficos
Main Authors: Pan, Qin, Wang, Qilong, Sun, Xiaoming, Xia, Xianru, Wu, Shimin, Luo, Fengling, Zhang, Xiao-Lian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015227/
https://ncbi.nlm.nih.gov/pubmed/24572295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.31
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