Aptamer Against Mannose-capped Lipoarabinomannan Inhibits Virulent Mycobacterium tuberculosis Infection in Mice and Rhesus Monkeys

The major surface lipoglycan of Mycobacterium tuberculosis (M. tb), mannose-capped lipoarabinomannan (ManLAM), is an immunosuppressive epitope of M. tb. We used systematic evolution of ligands by exponential enrichment (SELEX) to generate an aptamer (ZXL1) that specifically bound to ManLAM from the...

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Bibliografiske detaljer
Main Authors: Pan, Qin, Wang, Qilong, Sun, Xiaoming, Xia, Xianru, Wu, Shimin, Luo, Fengling, Zhang, Xiao-Lian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015227/
https://ncbi.nlm.nih.gov/pubmed/24572295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.31
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