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RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells, due to defective translocation of both Lck a...

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Main Authors: Chae, Hee-Don, Siefring, Jamie E., Hildeman, David A., Gu, Yi, Williams, David A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980477/
https://ncbi.nlm.nih.gov/pubmed/21103055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013970
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