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RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells, due to defective translocation of both Lck a...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2980477/ https://ncbi.nlm.nih.gov/pubmed/21103055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013970 |
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