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Mutations in the C-terminal region of the HIV-1 reverse transcriptase and their correlation with drug resistance associated mutations and antiviral treatment

OBJECTIVE: Replication of HIV-1 after cell entry is essentially dependent on the reverse transcriptase (RT). Antiretroviral drugs impairing the function of the RT currently aim at the polymerase subunit. One reason for failure of antiretroviral treatment is the evolvement of resistance-associated mu...

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Bibliografiske detaljer
Main Authors: Michels, I, Staszewski, S, Gürtler, L, Nisius, G, Müller, A, Locher, L, Doerr, H-W, Stürmer, M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352185/
https://ncbi.nlm.nih.gov/pubmed/21156400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2047-783X-15-10-415
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