Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways that traverse mitochondria are actually increased....

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Bibliographic Details
Main Authors: Satapati, Santhosh, Sunny, Nishanth E., Kucejova, Blanka, Fu, Xiaorong, He, Tian Teng, Méndez-Lucas, Andrés, Shelton, John M., Perales, Jose C., Browning, Jeffrey D., Burgess, Shawn C.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2012
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351815/
https://ncbi.nlm.nih.gov/pubmed/22493093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M023382
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