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The effect of a HFD on mitochondrial metabolism depends on nutritional state and mTORC1 activation

Dysregulated mitochondrial metabolism during hepatic insulin resistance may contribute to pathophysiologies ranging from elevated glucose production to hepatocellular oxidative stress and inflammation. Since obesity impairs insulin action but paradoxically activates mTORC1, we tested whether insulin...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Kucejova, Blanka, Duarte, Joao, Satapati, Santhosh, Fu, Xiaorong, Ilkayeva, Olga, Newgard, Christopher B., Brugarolas, James, Burgess, Shawn C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951107/
https://ncbi.nlm.nih.gov/pubmed/27346353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.006
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