Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma

Mammalian target of rapamycin complex 1 (mTORC1) is implicated in cell growth control and is extensively regulated. We previously reported that in response to hypoxia, mTORC1 is inhibited by the protein regulated in development and DNA damage response 1 (REDD1). REDD1 is upregulated by HIF-1, and fo...

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Autori principali: Kucejova, Blanka, Peña-Llopis, Samuel, Yamasaki, Toshinari, Sivanand, Sharanya, Tran, Tram Anh T., Alexander, Shane, Wolff, Nicholas C., Lotan, Yair, Xie, Xian-Jin, Kabbani, Wareef, Kapur, Payal, Brugarolas, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234675/
https://ncbi.nlm.nih.gov/pubmed/21798997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0302
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