Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis

BACKGROUND: Ewing sarcoma patients have a poor prognosis despite multimodal therapy. Integration of combination immunotherapeutic strategies into first-/second-line regimens represents promising treatment options, particularly for patients with intrinsic or acquired resistance to conventional therap...

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Autors principals: Berghuis, Dagmar, Schilham, Marco W, Vos, Hanneke I, Santos, Susy J, Kloess, Stephan, Buddingh', Emilie P, Egeler, R Maarten, Hogendoorn, Pancras CW, Lankester, Arjan C
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351702/
https://ncbi.nlm.nih.gov/pubmed/22587892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3329-2-8
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