The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease

BACKGROUND: Chemokine receptor CXCR4, together with its ligand CXCL12, plays critical roles in cancer progression, including growth, metastasis and angiogenesis. Ewing sarcoma is a sarcoma with poor prognosis despite current therapies, particularly for patients with advanced-stage disease. Lungs and...

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Main Authors: Berghuis, Dagmar, Schilham, Marco W, Santos, Susy J, Savola, Suvi, Knowles, Helen J, Dirksen, Uta, Schaefer, Karl-Ludwig, Vakkila, Jukka, Hogendoorn, Pancras CW, Lankester, Arjan C
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549731/
https://ncbi.nlm.nih.gov/pubmed/23249693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3329-2-24
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