Macrophage-Specific ApoE Gene Repair Reduces Diet-Induced Hyperlipidemia and Atherosclerosis in Hypomorphic Apoe Mice

BACKGROUND: Apolipoprotein (apo) E is best known for its ability to lower plasma cholesterol and protect against atherosclerosis. Although the liver is the major source of plasma apoE, extra-hepatic sources of apoE, including from macrophages, account for up to 10% of plasma apoE levels. This study...

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Bibliografiska uppgifter
Huvudupphovsmän: Gaudreault, Nathalie, Kumar, Nikit, Olivas, Victor R., Eberlé, Delphine, Rapp, Joseph H., Raffai, Robert L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351426/
https://ncbi.nlm.nih.gov/pubmed/22606237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035816
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