Inducible Apoe Gene Repair in Hypomorphic ApoE Mice Deficient in the LDL Receptor Promotes Atheroma Stabilization with a Human-like Lipoprotein Profile

OBJECTIVE: To study atherosclerosis regression in mice following plasma lipid reduction to moderately elevated apolipoprotein B (apoB)-lipoprotein levels. APPROACH AND RESULTS: Chow-fed hypomorphic Apoe mice deficient in LDL receptor expression (Apoe(h/h)Ldlr(−/−)Mx1-cre mice) develop hyperlipidemia...

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Detalhes bibliográficos
Main Authors: Eberlé, Delphine, Luk, Fu Sang, Kim, Roy Y., Olivas, Victor R., Kumar, Nikit, Posada, Jessica M., Li, Kang, Gaudreault, Nathalie, Rapp, Joseph H., Raffai, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811094/
https://ncbi.nlm.nih.gov/pubmed/23788760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300605
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