ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium

OBJECTIVE: We investigated atheroprotective properties of apoE beyond its ability to lower plasma cholesterol. We hypothesized that apoE reduces atherosclerosis by decreasing lipid accumulation in circulating monocytes and the inflammatory state of monocytes and the vascular endothelium. METHODS AND...

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Detalhes bibliográficos
Main Authors: Gaudreault, Nathalie, Kumar, Nikit, Posada, Jessica M., Stephens, Kyle B., de Mochel, Nabora Soledad Reyes, Eberle, Delphine, Olivas, Victor R., Kim, Roy Y., Harms, Matthew J., Johnson, Amy, Messina, Louis M., Rapp, Joseph H., Raffai, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275345/
https://ncbi.nlm.nih.gov/pubmed/22053073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.238964
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