The Immunosuppressant FTY720 Prolongs Survival in a Mouse Model of Diet-induced Coronary Atherosclerosis and Myocardial Infarction

FTY720, an analogue of sphingosine-1-phosphate, is cardioprotective during acute injury. Whether long-term FTY720 affords cardioprotection is unknown. Here we report the effects of oral FTY720 on ischemia/reperfusion (I/R) injury and in HypoE mice deficient in SR-BI receptor expression (ApoeR61(h/h)...

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Publicado en:J Cardiovasc Pharmacol
Autores principales: Wang, Guanying, Kim, Roy Y., Imhof, Isabella, Honbo, Norman, Luk, Fu Sang, Li, Kang, Kumar, Nikit, Zhu, Bo-qing, Eberlé, Delphine, Ching, Daniel, Karliner, Joel S., Raffai, Robert L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574629/
https://ncbi.nlm.nih.gov/pubmed/24508946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000031
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