Antiviral activity and possible mechanisms of action of oligonucleotides-poly(L-lysine) conjugates targeted to vesicular stomatitis virus mRNA and genomic RNA.

Synthetic oligonucleotides (oligomers) complementary to vesicular stomatitis virus (VSV) N protein mRNA have specific antiviral properties at concentrations lower than 1 microM when they are covalently linked to poly(L-lysine) (PLL). Since it is generally postulated that antisense oligomers act at t...

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Bibliographische Detailangaben
Hauptverfasser: Degols, G, Leonetti, J P, Gagnor, C, Lemaitre, M, Lebleu, B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1989
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC335136/
https://ncbi.nlm.nih.gov/pubmed/2479915
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