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Antiviral activity and possible mechanisms of action of oligonucleotides-poly(L-lysine) conjugates targeted to vesicular stomatitis virus mRNA and genomic RNA.

Synthetic oligonucleotides (oligomers) complementary to vesicular stomatitis virus (VSV) N protein mRNA have specific antiviral properties at concentrations lower than 1 microM when they are covalently linked to poly(L-lysine) (PLL). Since it is generally postulated that antisense oligomers act at t...

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Udgivet i:Nucleic Acids Res
Principais autores: Degols, G, Leonetti, J P, Gagnor, C, Lemaitre, M, Lebleu, B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1989
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC335136/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2479915/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.22.9341
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