Toll-like Receptor Activation of Human Cells by Synthetic Triacylated Lipid A-like Molecules

Recognition of microbial molecules by mammalian host receptors is essential to mount an immune response. Hexaacylated LPS is the prototypic example of a bacterial molecule recognized by the receptor complex TLR4/MD-2 with its lipid A moiety, whereas bacterial lipopeptides are recognized by TLR2. Her...

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Bibliografiska uppgifter
Huvudupphovsmän: Dunn-Siegrist, Irène, Tissières, Pierre, Drifte, Geneviève, Bauer, Jacques, Moutel, Stéphane, Pugin, Jérôme
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351317/
https://ncbi.nlm.nih.gov/pubmed/22433865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348383
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