Non-iminosugar glucocerebrosidase small molecule chaperones

Small molecule chaperones are a promising therapeutic approach for the Lysosomal Storage Disorders (LSDs). Here, we report the discovery of a new series of non-iminosugar glucocerebrosidase inhibitors with chaperone capacity, and describe their structure activity relationship (SAR), selectivity, cel...

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Detalhes bibliográficos
Main Authors: Marugan, Juan Jose, Huang, Wenwei, Motabar, Omid, Zheng, Wei, Xiao, Jingbo, Patnaik, Samarjit, Southall, Noel, Westbroek, Wendy, Lea, Wendy A., Simeonov, Anton, Goldin, Ehud, DeBernardi, Maria A., Sidransky, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351140/
https://ncbi.nlm.nih.gov/pubmed/22606365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C1MD00200G
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