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Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality

Glucose-6-phosphatase-β (G6Pase-β or G6PC3) deficiency, also known as severe congenital neutropenia syndrome 4, is characterized not only by neutropenia but also by impaired neutrophil energy homeostasis and functionality. We now show the syndrome is also associated with macrophage dysfunction, with...

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Autors principals: Jun, Hyun Sik, Cheung, Yuk Yin, Lee, Young Mok, Mansfield, Brian C., Chou, Janice Y.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350367/
https://ncbi.nlm.nih.gov/pubmed/22246029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-377820
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