G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis

G6PC3 (or glucose-6-phosphatase-β) deficiency underlies a congenital neutropenia syndrome in which neutrophils exhibit enhanced endoplasmic reticulum (ER) stress, increased apoptosis, impaired energy homeostasis, and impaired functionality. Here we show that murine G6pc3(−/−) neutrophils undergoing...

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Detalhes bibliográficos
Principais autores: Jun, Hyun Sik, Lee, Young Mok, Song, Ki Duk, Mansfield, Brian C., Chou, Janice Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083300/
https://ncbi.nlm.nih.gov/pubmed/21292774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-302059
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