Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation

OBJECTIVE: Common genetic variants in a 58-kilobase region of chr 9p21, near the CDKN2A/CDKN2B tumor suppressor locus, are strongly associated with coronary artery disease. However, the underlying mechanism of action remains unknown. METHODS AND RESULTS: We previously reported a congenic mouse model...

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Autori principali: Kuo, Chao-Ling, Murphy, Andrew J., Sayers, Scott, Li, Rong, Yvan-Charvet, Laurent, Davis, Jaeger Z., Krishnamurthy, Janakiraman, Liu, Yan, Puig, Oscar, Sharpless, Norman E., Tall, Alan R., Welch, Carrie L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350106/
https://ncbi.nlm.nih.gov/pubmed/21868699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.234492
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