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Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS
Riluzole is the only FDA-approved drug to treat amyotrophic lateral sclerosis, but its long-term effects on motoneurons are unknown. Therefore, we treated primary mouse spinal cord cultures with 2 μM riluzole for 4–9 days and then used whole cell patch clamp to record the passive and active properti...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349692/ https://ncbi.nlm.nih.gov/pubmed/22013234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00714.2011 |
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