Human FOXN1-Deficiency Is Associated with αβ Double-Negative and FoxP3+ T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

Forkhead box N1 (FOXN1) is a transcription factor crucial for thymic epithelium development and prevention of its involution. Investigation of a patient with a rare homozygous FOXN1 mutation (R255X), leading to alopecia universalis and thymus aplasia, unexpectedly revealed non-maternal circulating T...

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Hauptverfasser: Albuquerque, Adriana S., Marques, José G., Silva, Susana L., Ligeiro, Dario, Devlin, Blythe H., Dutrieux, Jacques, Cheynier, Rémi, Pignata, Claudio, Victorino, Rui M. M., Markert, M. Louise, Sousa, Ana E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349657/
https://ncbi.nlm.nih.gov/pubmed/22590644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037042
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