Postnatal Tissue-specific Disruption of Transcription Factor FoxN1 Triggers Acute Thymic Atrophy

The transcription factor FoxN1 is essential for differentiation of thymic epithelial cell (TEC) progenitors during thymic organogenesis. However, limited information is available on the postnatal contribution of FoxN1 to thymic maintenance. To address this question, we generated a loxP-floxed FoxN1...

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Bibliographic Details
Main Authors: Cheng, Lili, Guo, Jianfei, Sun, Liguang, Fu, Jian, Barnes, Peter F., Metzger, Daniel, Chambon, Pierre, Oshima, Robert G., Amagai, Takashi, Su, Dong-Ming
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820809/
https://ncbi.nlm.nih.gov/pubmed/19955175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072124
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