Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

The p63 gene regulates thymic epithelial cell (TEC) proliferation, whereas FoxN1 regulates their differentiation. However, their collaborative role in the regulation of TEC homeostasis during thymic aging is largely unknown. In murine models, the proportion of TAp63(+), but not ΔNp63(+), TECs was in...

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Autori principali: Burnley, P, Rahman, M, Wang, H, Zhang, Z, Sun, X, Zhuge, Q, Su, D-M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847336/
https://ncbi.nlm.nih.gov/pubmed/24263106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.460
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