IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

Naive CD4 T-cell maintenance is critical for immune competence. We investigated here the fine-tuning of homeostatic mechanisms of the naive compartment to counteract the loss of de novo CD4 T-cell generation. Adults thymectomized in early childhood during corrective cardiac surgery were grouped base...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Silva, Susana L., Albuquerque, Adriana S., Matoso, Paula, Charmeteau-de-Muylder, Bénédicte, Cheynier, Rémi, Ligeiro, Dário, Abecasis, Miguel, Anjos, Rui, Barata, João T., Victorino, Rui M. M., Sousa, Ana E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243809/
https://ncbi.nlm.nih.gov/pubmed/28154568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00020
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