Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration

Mithramycin A (MTM) and histone deacetylase inhibitors (HDACi) are effective therapeutic agents for cancer and neurodegenerative diseases. MTM is a FDA approved aureolic acid-type antibiotic that binds to GC-rich DNA sequences and interferes with Sp1 transcription factor binding to its target sites...

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Autores principales: Sleiman, Sama F., Berlin, Jill, Basso, Manuela, S.Karuppagounder, Saravanan, Rohr, Jürgen, Ratan, Rajiv R.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349345/
https://ncbi.nlm.nih.gov/pubmed/22582024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph4081183
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