Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration

Oncogenic transformation of postmitotic neurons triggers cell death, but the identity of genes critical for degeneration remain unclear. The antitumor antibiotic mithramycin prolongs survival of mouse models of Huntington's disease in vivo and inhibits oxidative stress-induced death in cortical...

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Auteurs principaux: Sleiman, Sama F., Langley, Brett C., Basso, Manuela, Berlin, Jill, Xia, Li, Payappilly, Jimmy B., Kharel, Madan K., Guo, Hengchang, Marsh, J. Lawrence, Thompson, Leslie Michels, Mahishi, Lata, Ahuja, Preeti, MacLellan, W. Robb, Geschwind, Daniel H., Coppola, Giovanni, Rohr, Jürgen, Ratan, Rajiv R.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2011
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717375/
https://ncbi.nlm.nih.gov/pubmed/21543616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0710-11.2011
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