Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration

Oncogenic transformation of postmitotic neurons triggers cell death, but the identity of genes critical for degeneration remain unclear. The antitumor antibiotic mithramycin prolongs survival of mouse models of Huntington's disease in vivo and inhibits oxidative stress-induced death in cortical...

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Autori principali: Sleiman, Sama F., Langley, Brett C., Basso, Manuela, Berlin, Jill, Xia, Li, Payappilly, Jimmy B., Kharel, Madan K., Guo, Hengchang, Marsh, J. Lawrence, Thompson, Leslie Michels, Mahishi, Lata, Ahuja, Preeti, MacLellan, W. Robb, Geschwind, Daniel H., Coppola, Giovanni, Rohr, Jürgen, Ratan, Rajiv R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717375/
https://ncbi.nlm.nih.gov/pubmed/21543616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0710-11.2011
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