CDC42 ACTIVITY REGULATES HEMATOPOIETIC STEM CELL AGING AND REJUVENATION

The functional decline in hematopoietic function seen during aging involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, and has been linked to aging of hematopoietic stem cells (HSCs). The molecular mechanisms underlying HSC aging remain unclear....

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Hauptverfasser: Florian, Maria Carolina, Dörr, Karin, Niebel, Anja, Daria, Deidre, Schrezenmeier, Hubert, Rojewski, Markus, Filippi, Marie-Dominique, Hasenberg, Anja, Gunzer, Matthias, Scharffetter-Kochanek, Karin, Zheng, Yi, Geiger, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348626/
https://ncbi.nlm.nih.gov/pubmed/22560076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.04.007
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